Theme Keynote Lecture
Dynamic Mapping and Interfacing with the Brain
Bin He, Ph.D.
Distinguished McKnight University Professor of Biomedical Engineering
2:20pm – 3:20pm
Brain activity is distributed over the 3-dimensional volume and evolves in time. Mapping spatio-temporal distribution of brain activation with high spatial resolution and high temporal resolution is of great importance for understanding the brain and aiding in the clinical diagnosis and management of brain disorders. Electrophysiological source imaging (ESI) from noninvasively recorded high density electroencephalogram (EEG) has played a significant role in advancing our ability to image brain function and dysfunction. Development in the past decades has led to the capability of localizing and imaging neural activation associated with cognition, sensory, and motor tasks in patients suffering from various neurological and mental disorders and healthy human subjects. We will discuss principles and current state of EEG-based ESI in localizing and imaging human brain activity with applications to seizure localization. Promising clinical results validated by intracranial recordings and surgical resection outcomes demonstrate the merits of noninvasive EEG-based ESI in mapping epileptogenic zones, aiding surgical treatment of intractable epilepsy. We will also discuss the merits and challenges of multimodal functional neuroimaging by integrating electrophysiological and hemodynamic measurements. Our work indicates that the BOLD functional MRI and EEG can be integrated in a principled way, leading to substantially enhanced spatio-temporal resolution for functional imaging of dynamic brain activation. Finally, we will discuss the co-localization of hemodynamic and electrophysiological signals, and discuss our recent progress in brain-computer interface, demonstrating that humans can control a quadcopter by “mind” from noninvasive EEG signals.
Bin He is a Distinguished McKnight University Professor of Biomedical Engineering, Medtronic-Bakken Endowed Chair for Engineering in Medicine, Director of the Institute for Engineering in Medicine, Director of the Center for Neuroengineering, and Director of the NSF IGERT Neuroengineering Training Program at the University of Minnesota. Dr. He’s research interests cover a broad spectrum in biomedical engineering, mainly in neuroengineering and biomedical imaging. He has made significant original contributions to electrophysiological source imaging, multimodal neuroimaging, and brain-computer interface. He has published over 200 peer reviewed journal articles and is the sole editor of the text book entitled Neural Engineering (2nd Ed, 2013). Dr. He is a recipient of the Outstanding Research Award from the International Federation of Clinical Neurophysiology, the Established Investigator Award from the American Heart Association, the Distinguished Service Award from IEEE Engineering in Medicine and Biology Society (EMBS), among others. A Fellow of IEEE, American Institute of Medical and Biological Engineering and Institute of Physics, Dr. He served as a Past President of IEEE EMBS, International Society for Functional Source Imaging, and International Society for Bioelectromagnetism. Dr. He is the Editor-in-Chief of IEEE Transactions on Biomedical Engineering, and was elected in 2012 to the International Academy of Medical and Biological Engineering.