4. Hybrid Microfluidic/CMOS Sensors for Cellular and Tissue Engineering

Organizers:  EbrahimGhafar-Zadeh, Sebastian Magierowski

Recent advances in micro- and nano-technologies have enabled the development of High-Throughput Screening (HTS) techniques for various applications including drug discovery. Owing to the seminal advances in micro-fabrication technologies, HTS is moving towards massively parallel, miniaturized, and label-free platforms. The state-of-the-art DNA sequencing platform featuring millions of Ion- Selective Field Effect Transistors (ISFETs) has convincingly demonstrated the advantage of using standard microelectronic information technologies such as Complementary Metal Oxide Semiconductor (CMOS) process in HTS applications. Similarly, many researchers addressed the challenge of developing HTS Systems for monitoring cellular activities on a single chip. Due to the significant advantages of CMOS-based biosensors, such as non-invasive long term recordings, fast response, and label-free processes, they have been widely applied in many biological and medical fields concerning the studying of the living-cell samples such as neural cell recording and stimulation, monitoring metabolic activity, cell manipulation, and extracellular pH monitoring, cellular and tissue engineering on chip and DNA sequencing.

This tutorial is organized as follows.

  • Introduction on Hybrid CMOS Systems for Cellular and Tissue Engineering (60 Minutes)
  • CMOS Sensing Techniques (Part I: 60 Minutes)
    • Electrochemical CMOS Sensors
    • Capacitives and Impedance Sensors
    • Optical CMOS
  • CMOS Sensing Techniques (Part II: 60 Minutes)
    • ISFET CMOS sensors
    • Nanopore CMOS Sensors.
    • Other CMOS Sensors and Actuators
  • Microfluidic CMOS Techniques (60 minutes)

List of Speakers

Ebrahim Ghafar-Zadeh received his PhD degree in Electrical Engineering from Ecole Polytechnique de Montreal, Canada, in 2008. In 2012, he was a postdoctoral fellow in the Dept. of Bio-engineering, University of Berkeley, USA. Currently he is an Assistant Professor, in the Dept. of EECS, York University, Toronto, Canada. Dr. Ghafar-Zadeh research interests is Biologically Inspired Sensors and Actuators.

Sebastian Magierowski received his PhD in Electrical Engineering from the University of Toronto in 2004. From 2004 to 2012 he served on the faculty of the Dept. of Electrical and Computer Engineering at the University of Calgary. Since 2013 he has served on the faculty of the Dept. of EECS at York University where he is an Associate Professor. Prof. Magierowski’s research interests centre on analog and digital integrated circuit design for biomedical applications in mobile computing contexts.