Multi-Scale Image-Based Modeling of the Failing Heart: From Cell to Patient


Andrew D. McCulloch

Distinguished Professor of Bioengineering and Medicine
Jacobs School Distinguished Scholar
University of California San Diego
La Jolla, CA 92093-0412

11:30 -12:30
Friday, 28 August 2015
Silver Room



Multi-scale models of the heart have been developed that integrate both functionally across biomechanical, electrophysiological and regulatory functions and structurally across physical scales of organization from molecule to organ system. Imaging is central to the development of multi-scale cardiac models at all scales of biological organization, especially in disease states such as heart failure where structural remodeling of cells, tissue and the whole heart are all key contributors to mechanical dysfunction and arrhythmia risk. Here, we illustrate the development and application of these imaged-derived computational models to improving understanding and treatment of heart disease using several examples including: Microanatomically detailed models of subcellular and cellular biophysics generated from 3D electron tomograms; multi-scale models of murine ventricular mechanics derived from mouse cardiac magnetic resonance imaging; and patient-specific computational models of human atrial fibrillation and dyssynchronous heart failure to improve diagnosis and treatment efficacy.


Dr. Andrew McCulloch is Distinguished Professor of Bioengineering and Medicine and Jacobs School Distinguished Scholar at the University of California San Diego, where he joined the faculty in 1987. He is member of the UCSD Institute for Engineering in Medicine, the Qualcomm Institute, a Senior Fellow of the San Diego Supercomputer Center, a Principal Investigator of the National Biomedical Computation Resource and Co-Director of the Cardiac Biomedical Science and Engineering Center. Dr. McCulloch was educated at the University of Auckland, New Zealand in Engineering Science and Physiology receiving his Ph.D. in 1986. Dr. McCulloch is a Fellow of the American Institute for Medical and Biological Engineering and currently serves as Associate Editor of PLoS Computational Biology and co-Editor-in-Chief of Drug Discovery Today: Disease Models. He is chair of the Physiome and Systems Biology Committee of the International Union of Physiological Sciences. Dr. McCulloch’s lab uses experimental and computational models to investigate the relationships between the cellular and extracellular structure of cardiac muscle and the electrical and mechanical function of the whole heart during ventricular remodeling, heart failure and arrhythmia.