The pressure-volume relationship (PVR) of the left ventricle was first documented more than 100 years ago. In early 70s, Suga demonstrated that the slope of the end-systolic pressure-volume relationship (Ees) is a sensitive index of ventricular contractility. In 80s, Sunagawa proposed an index of afterload, effective arterial elastance (Ea), to couple the ventricle with the vasculature (Ventriculo-arterial coupling: VA coupling). The VA coupling makes it possible to translate the mechanical properties of the ventricle and afterload into physiological cardiac pump function. Because of such versatility and expandability of the framework, many groups in the world investigated, validated and applied the PVR and VA coupling in pathophysiological conditions as well as in physiological conditions. In this workshop, we would like to discuss every aspect of PVR in patients and in animals including RV function and the impact of autonomic regulation on the PVR and VA coupling. This workshop is the most thorough review of the latest knowledge of PVR. All lectures will be delivered by the first rated instructors who truly contributed and added life to the PVR. I recommend that every student and scientist who is interested in cardiac mechanics should participate in the workshop. We never disappoint you. All participants will get handouts of lectures.
Kenji Sunagawa, Professor, Center for Disruptive Cardiovascular Medicine, Kyushu University, Fukuoka, Japan
Kenji Sunagawa (Kyushu University, Japan)
Paul Steendijk (Leiden University, The Netherlands)
Louis Handoko (Free University Medical Centre, The Netherlands):
Reinout Borgdorff (University Medical Center Groningen, The Netherlands)
Takafumi Sakamoto (Kyushu University, Japan)
Masaru Sugimachi (National Cerebral and Cardiovascular Center, Japan)